骨髓移植:一个二十年的单中心血液学经验
Rajiv Kumar1, Rajan Kapoor2, Sanjeevan Sharma3
1Senior Advisor (Medicine) & Clinical Hematologist, Army Hospital (R&R), New Delhi, India.
Medical journal, Armed Forces India
|November 20, 2023
概括
骨髓移植 (BMT) 为血液学疾病提供治愈疗法. 扩大了捐赠者选择,包括平分身份移植,确保更多的患者获得拯救生命的BMT,解决"为所有人进行移植"的目标.
科学领域:
- 血液学 血液学 血液学
- 移植免疫学 移植免疫学
- 在瘤学瘤学.
背景情况:
- 骨髓移植 (BMT) 是成人和儿童血液学疾病的关键治愈疗法.
- 20多年来,建立一个BMT计划已经显著改善了患者的治疗结果.
研究的目的:
- 审查骨髓移植 (BMT) 计划数据,从其开始到2023年2月.
- 分析所治疗的血液学疾病类型,移植方式和患者人口统计.
主要方法:
- 骨髓移植 (BMT) 计划数据的回顾性审查.
- 分析了700多名患者的病例,这些患者因各种血液病症接受了BMT治疗.
主要成果:
- 超过700名患有超过23种血液学疾病的患者接受了BMT.
- 自主 BMT (58%) 是多发性髓瘤的常见病例;异性 BMT (42%) 是无性贫血和急性白血病的常见病例.
- 该计划从匹配的兄弟捐赠者 (MSD) 扩展到包括匹配的无亲属捐赠者 (MUD) 和偶然的捐赠者移植,其中93%的全基因病例是MSD.
结论:
- BMT 计划的演变使得一个新的世界成为可能.
- 为所有人进行移植.
- 通过扩大捐赠者选择的方式.
- 对于非恶性血液学疾病的哈普罗同一HSCT仍然是一个开发领域.
- 未来的优先事项包括整合CAR T细胞疗法和其他细胞疗法.
相关概念视频
Bone Marrow Sampling and Transplants
334
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
334
Stem Cell Therapy for Tissue Regeneration
4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
Tissue Transplantation
375
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
375


