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Updated: Jul 10, 2025

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
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由EZH2抑制驱动的代谢重编程取决于细胞矩阵相互作用

Teresa W-M Fan1, Jahid M M Islam2, Richard M Higashi1

  • 1Center for Environmental and System Biochemistry, University of Kentucky, Lexington, Kentucky, USA; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky, USA; Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA.

The Journal of biological chemistry
|November 22, 2023
PubMed
概括

抑制EZH2减少了2D培养中的肺癌细胞生长,但在3D中刺激了它,改变了代谢途径. 细胞外矩阵的组成显著影响EZH2抑制剂的有效性,这对于体内建模至关重要.

关键词:
在 EZH2 中使用.稳定的同位素溶解代谢物质.细胞外矩阵是细胞外矩阵.葡萄糖/谷氨酸的新陈代谢.球形状的球形体是指球形体.

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