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Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
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Updated: Jul 8, 2025

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

周围T淋巴细胞的TIM3表达与中风后抑郁症之间的关系

Qifen Mao¹, Peng Zhang², Weicui Qi³

¹Department of Clinical Laboratory, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310012, China.

Iranian journal of immunology : IJI

|December 16, 2023

概括

脑卒中后抑郁症 (PSD) 与免疫功能障碍有关. 在CD8+ T细胞上增加的T细胞免疫球蛋白和粘素域含有蛋白3 (TIM3) 与PSD严重程度相关,表明TIM3是治疗点.

关键词:

介质蛋白是介质蛋白中的一种.含有氨酸域的蛋白质 3 3 脑卒中后的抑郁症脑卒中后的抑郁症治疗目标治疗目标一个T淋巴细胞.

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Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

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科学领域:

免疫学免疫学免疫学
神经科学是一个神经科学.
精神病学是一个精神病学.

背景情况:

T细胞免疫球蛋白和粘素域含蛋白3 (TIM3) 是T细胞上的一个调节分子.
关于T淋巴细胞上TIM3表达与中风后抑郁症 (PSD) 之间的相关性,研究有限.

研究的目的:

为了研究TIM3表达在外围T淋巴细胞和PSD之间的关系.

主要方法:

流细胞计用于检查TIM3表达在CD3+CD4+和CD3+CD8+T淋巴细胞在急性中风患者 (NPSD,PSD) 和健康对照 (HC).
使用汉密尔顿抑郁症评分表 (HAM-D-17) 评估抑郁症的严重程度.
血清细胞因子水平 (IL-1β,IL-6,IL-10,IL-18) 通过ELISA测量.

主要成果:

与NPSD患者和HC患者相比,PSD患者的CD3+CD4+T细胞减少.
无论是NPSD还是PSD患者都在CD3+CD4+T淋巴细胞上增加了TIM3表达,而不是HC.
PSD患者在CD3+CD8+T淋巴细胞上表现出更高的TIM3表达,与HAM-D得分积极相关.

结论:

PSD患者表现出免疫功能障碍.
在外围CD3+CD8+T淋巴细胞上的TIM3表达与PSD严重程度有关.
TIM3可能是PSD的潜在治疗点.