Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A continuous-discrete model of cell contraction incorporating actin and intermediate filaments.

iScience·2026
Same author

CLEC14A correlates with neutrophil infiltration in hepatocellular carcinoma and mediates neutrophil recruitment across liver endothelial cells.

The Journal of pathology·2026
Same author

Adaptive dynamics of diverging fitness optima.

Journal of mathematical biology·2025
Same author

The Human Cardiac "Age-OME": Age-Specific Changes in Myocardial Molecular Expression.

Aging cell·2025
Same author

Edge curvature drives endoplasmic reticulum reorganization and dictates epithelial migration mode.

Nature cell biology·2025
Same author

Lactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution.

Nature metabolism·2025

相关实验视频

Updated: Jul 6, 2025

In Vitro Model Integrating Substrate Stiffness and Flow to Study Endothelial Cell Responses
08:53

In Vitro Model Integrating Substrate Stiffness and Flow to Study Endothelial Cell Responses

Published on: July 19, 2024

499

一个机械建模框架来研究内皮透气性.

Pradeep Keshavanarayana1, Fabian Spill1

  • 1School of Mathematics, University of Birmingham, Birmingham, United Kingdom.

Biophysical journal
|January 3, 2024
PubMed
概括
此摘要是机器生成的。

这项研究通过检查VE-cadherin键,模拟机械力和化学信号如何影响血管透性. 机械化学建模揭示了细胞结点和基质刚度如何影响粒子通过,这对于理解疾病至关重要.

更多相关视频

Author Spotlight: Automated Bioprinting for High-Throughput Vascular Model Fabrication
07:41

Author Spotlight: Automated Bioprinting for High-Throughput Vascular Model Fabrication

Published on: August 16, 2024

1.0K
In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

9.0K

相关实验视频

Last Updated: Jul 6, 2025

In Vitro Model Integrating Substrate Stiffness and Flow to Study Endothelial Cell Responses
08:53

In Vitro Model Integrating Substrate Stiffness and Flow to Study Endothelial Cell Responses

Published on: July 19, 2024

499
Author Spotlight: Automated Bioprinting for High-Throughput Vascular Model Fabrication
07:41

Author Spotlight: Automated Bioprinting for High-Throughput Vascular Model Fabrication

Published on: August 16, 2024

1.0K
In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

9.0K

科学领域:

  • 生物物理学的生物物理.
  • 细胞生物学 细胞生物学
  • 机械生物学 机械生物学

背景情况:

  • 内皮细胞形成血管内膜,通过VE-cadherin键调节透性.
  • 异常的内皮通透性与心血管疾病,癌症和COVID-19等疾病有关.
  • 机械和化学刺激对内皮透性的同时影响尚未完全理解.

研究的目的:

  • 开发一个连续级机械建模框架,用于动态VE-cadherin键.
  • 为了研究actin细胞骨架和基质在内皮透气性中的作用.
  • 了解如何结合机械和化学刺激影响内皮屏障功能.

主要方法:

  • 模拟VE-cadherin键使用与损伤的凝聚性接触和引分离定律.
  • 将actin细胞骨架和基质力学纳入模型.
  • 开发了一种基于接触力学的机械化学模型.

主要成果:

  • 机械化学合对于模拟基板机械性能对透性的影响至关重要.
  • 细胞剪切解释了双细胞和三细胞结点之间的透性差异.
  • 增加的引力和基质刚度提高了内皮透气性.

结论:

  • 该模型阐明了通过机械和化学线索对内皮透气性的动态调节.
  • 机械化学相互作用对于基质依赖的透性至关重要.
  • 单层几何学 (圆柱形与平面形) 影响了整体的透性.