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怀孕期间白细胞计数的综合参考间隔
Jinxiu Zhu1,2, Zexin Li1,2, Yuguo Deng3,1
1Longgang Maternity and Child Institute of Shantou University Medical College, Shenzhen, Guangdong, 518172, China.
BMC pregnancy and childbirth
|January 5, 2024
概括
怀孕涉及白细胞 (WBC) 数量上升. 这项研究确定了怀孕期间白血细胞的新参考间隔,这对于识别感染和怀孕并发症风险至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 血液学 血液学 血液学
- 临床病理学 临床病理学
背景情况:
- 白细胞 (WBC) 数量在怀孕期间自然增加.
- 准确的参考间隔对于诊断孕妇感染和并发症至关重要.
- 现有的参考范围可能无法充分反映妊娠期间的生理变化.
研究的目的:
- 为了建立全面的,针对怀孕的白细胞计数 (WBC) 的具体参考间隔.
- 为了将白细胞计数变化与妊娠阶段相关联,并确定潜在的临床影响.
- 为怀孕期间监测母亲健康提供更新的指导方针.
主要方法:
- 分析了来自17737名孕妇的每周WBC计数,从怀孕前到产后.
- 使用值线性回归建模来确定参考间隔.
- 采用哈里斯和博伊德的测试来划分和验证已建立的间隔.
主要成果:
- 在整个怀孕期间,观察到白细胞计数的显著,逐渐增加,特别是在中性粒细胞中.
- 建立了分割的参考间隔:<=2周 (4.0-10.0 × 10^9/L),3-5周 (4.7-11.9 × 10^9/L) 和>=6周 (5.7-14.4 × 10^9/L).
- 在这些间隔内增加的白细胞计数与增加的并发症发病率相关,如胎盘前期和子宫内生长限制.
结论:
- 这项研究成功地建立了新的,孕期年龄特定的WBC计数在怀孕个体的参考间隔.
- 使用这些更新的间隔监测WBC计数对于早期检测感染和不良妊娠结果具有临床意义.
- 这些发现强调了特定背景的参考范围在产科护理中的重要性.
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