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Updated: Jul 6, 2025

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
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一个构建块方法,用于YM-385781的总合成.

Yu Zhu1, Siyue Liu1, Johnny Zigmond1

  • 1Department of Chemistry, Washington University, St. Louis, MO 63130.

European journal of organic chemistry
|January 8, 2024
PubMed
概括

研究人员开发了一种新的合成方法,用于制造Gq/11信号通路抑制剂YM-254890和FR900359.9的类似物. 这种方法可以有效地生产各种非天然和标记化合物,以便进一步研究.

关键词:
循环合成 循环合成抑制剂是一种抑制剂.YM-类型的类似产品

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相关概念视频

Preparation of 1° Amines: Gabriel Synthesis01:28

Preparation of 1° Amines: Gabriel Synthesis

Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
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