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降解器TCM:用于预测三级降解复合物的计算节约方法.

Paolo Rossetti1, Giulia Apprato1, Giulia Caron1

  • 1University of Torino, Department of Molecular Biotechnology and Health Sciences, CASSMedChem, Piazza Nizza 44, 10126 Torino, Italy.

ACS medicinal chemistry letters
|January 17, 2024
PubMed
概括

降解器TCM是一种新的计算工具,可以模拟蛋白质分解向金像体 (PROTAC) 三元复合体. 该方法通过预测降解活性和结构-活性关系,有助于设计PROTAC药物.

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