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相关概念视频

The Parathyroid Glands00:59

The Parathyroid Glands

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
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Hormones and Bone Tissue01:17

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers01:26

Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers

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Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
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Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

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The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
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Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

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Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
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偏甲状腺功能障碍和周围动脉疾病.

Pier Luigi Antignani1, Mateja K Jezovnik2, Ales Blinc3,4

  • 1Vascular Centre Nuova Villa Claudia, Rome, Italy.

Current vascular pharmacology
|January 29, 2024
PubMed
概括

原发性副甲状腺功能障碍症 (PHPT) 和二次性副甲状腺功能障碍症会增加副甲状腺激素 (PTH) 水平,导致动脉样硬化和心血管风险. 副甲状腺切除术是严重PHPT的主要治疗方法.

关键词:
甲状腺上腺激素激素的作用慢性高血症 慢性高血症甲状腺功能障碍症. 甲状腺功能障碍症.副甲状腺切除术 (parathyroidectomy) 是一种切除甲状腺的方法.周围动脉疾病 周围动脉疾病血管化的情况.

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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
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相关实验视频

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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
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科学领域:

  • 内分泌学 在内分泌学.
  • 心血管医学 心血管医学
  • 腎臟病學 (nephrology) 是一種醫學專業.

背景情况:

  • 甲状腺功能障碍症 (HPT),包括初级 (PHPT) 和二级 (SHPT) 形式,涉及甲状腺类激素 (PTH) 水平升高.
  • SHPT通常是由维生素D缺乏或功能衰竭引起的.
  • PHPT存在各种形式,如经典,normohormonal和normocalcemic等.

研究的目的:

  • 审查HPT在动脉样硬化的发展中的作用,包括周围动脉疾病 (PAD).
  • 探索PTH升高与心血管疾病和死亡率之间的关联.

主要方法:

  • 文献综述专注于将HPT与血管疾病联系起来的病理生理机制.
  • 对研究PTH对内皮功能,血管硬和高血压的影响的分析.

主要成果:

  • 增加的PTH水平与内皮功能障碍,血管硬,高血压以及冠状动脉和外周动脉疾病有关.
  • 在HPT中的慢性高血症促进了血管和动脉样硬化斑块的化.
  • HPT是心血管疾病发病率和死亡率的独立风险因素.

结论:

  • 升高的PTH显著导致动脉样硬化和心血管并发症.
  • 虽然对于SHPT存在诸如仿药等治疗方法,但副甲状腺切除术仍然是严重PHPT的主要治疗选择.