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Updated: Jun 14, 2026

Mutagenesis and Functional Analysis of Ion Channels Heterologously Expressed in Mammalian Cells
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Mutagenesis and Functional Analysis of Ion Channels Heterologously Expressed in Mammalian Cells

Published on: October 1, 2010

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基于模拟研究,预测对TMEM16A的Ca2+活性导的突变效应

Yue Zhang1,2, Kang Wu3, Yuqing Li3

  • 1Warshel Institute for Computational Biology, School of Life and Health Sciences, School of Medicine, The Chinese University of Hong Kong (Shenzhen), Shenzhen 518172, China.

Journal of the American Chemical Society
|February 6, 2024
PubMed
概括

本研究引入了一种计算方法来预测突变如何影响离子通道功能,使用TMEM16A通道作为模型. 该方法在预测突变效应方面实现了94%的准确性,为道机制提供了宝贵的见解.

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Author Spotlight: Functional Site-Directed Fluorometry in Native Cells to Study Skeletal Muscle Excitability12:26

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相关概念视频

Patch Clamp01:18

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...