在设计和解释适应性临床试验时考虑权力考虑因素.
Rui Wang1,2, Cyrus Mehta2,3
1Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston.
NEJM evidence
|February 6, 2024
概括
适应性临床试验允许实时修改研究. 在治疗源不明的栓塞性中风的阿皮克萨班 (ATTICUS) 试验中,在患有心血管栓塞风险因素的患者中,评估了阿皮克萨班与阿司匹林的对比.
科学领域:
- 临床试验 临床试验
- 心血管研究研究心血管研究
- 神经学 神经学
背景情况:
- 适应性临床试验在研究设计中提供了灵活性,允许基于中间数据进行预先计划的修改.
- 这些修改可以优化试验的效率和有效性,包括样本大小调整和治疗改变.
- 在治疗源不明的栓塞性中风的阿皮克萨班 (ATTICUS) 试验中,在患有心血管栓塞风险因素的患者中,研究了阿皮克萨班与阿司匹林的对比.
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