对多变量纵向和时间到事件数据的贝叶斯定量联合建模.
Damitri Kundu1, Shekhar Krishnan2, Manash Pratim Gogoi2
1Applied Statistics Division, Indian Statistical Institute, Kolkata, India.
Lifetime data analysis
|March 1, 2024
概括
这项研究引入了贝叶斯量子式联合模型,用于分析急性淋巴细胞白血病 (ALL) 患者的纵向生物标志物和复发时间. 该模型显示,较高的淋巴细胞计数增加了复发风险,而较高的中性粒细胞和血小板计数降低了复发风险,并观察到特定的药物效应.
科学领域:
- 生物统计学 生物统计学
- 临床研究 临床研究
- 计算生物学 计算生物学
背景情况:
- 传统的线性混合模型与非高斯纵向数据和事件时间结果扎.
- 量子回归为非高斯数据提供了更合适的方法,允许在不同结果层面进行分析.
- 了解时间变化的共变量如何影响各种结果量度的事件时间对于复杂疾病至关重要.
研究的目的:
- 开发和应用贝叶斯量子式联合模型,同时分析急性淋巴细胞白血病 (ALL) 患者的纵向生物标志物和复发时间.
- 为了研究纵向生物标志物水平对不同量度的复发风险的影响.
- 评估治疗 (6MP和MTx) 对生物标志物的影响及其与复发时间的关系.
主要方法:
- 为三个纵向生物标志物 (淋巴细胞,中性粒细胞,血小板数) 和复发时间开发了贝叶斯定量联合模型.
- 不对称拉普拉斯分布 (ALD) 用于结果,其混合物表示使得基布斯采样算法能够进行参数估计.
- 该模型允许每个生物标志物的不同量子级别,同时对特定量子组合的回归系数进行估计.
主要成果:
- 发现较高的淋巴细胞计数加速了复发风险,而较高的中性粒细胞和血小板计数共同降低了复发风险.
- 药物6 - 默卡普托普林 (6MP) 被推断为减少大多数量体中淋巴细胞的数量.
- 药物甲状腺素 (MTx) 被推断为在大多数量体中增加中性粒细胞计数.
结论:
- 提出的贝叶斯定量联合模型有效地分析复杂的纵向数据和癌症研究中的事件时间结果.
- 生物标志物水平对ALL患者的复发风险有显著的,依赖于量子的影响.
- 特定的化疗药物对生物标志物轨迹有不同的影响,因此对复发风险有不同的影响.
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