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相关概念视频

Self-Evaluation Maintenance Model01:29

Self-Evaluation Maintenance Model

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The Self-Evaluation Maintenance (SEM) model offers a psychological framework to understand how individuals’ self-esteem is influenced by the achievements of others, particularly those with whom they share close personal bonds. The SEM model operates when personal rather than social identity guides individuals. Central to this model is the notion that individuals have an inherent desire to preserve a favorable self-image, which is continuously shaped by interpersonal comparisons and...
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Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
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Structural Joints: Fibrous Joints01:03

Structural Joints: Fibrous Joints

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Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
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Structural Joints: Cartilaginous Joints01:17

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As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
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Joints, also called articulations or articular surfaces, are points at which ligaments or other tissues connect adjacent bones. Joints permit movement and stability, and can be classified based on their structure or function.
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Fibrous Joints Are Immovable
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Drugs can be classified according to their chemical composition or their intended therapeutic application. For instance, anti-infective agents that possess the ability to eliminate pathogens or suppress their growth and reproduction can be grouped based on the organisms they target or their chemical structure. Furthermore, drugs can be divided into prescription, nonprescription, or controlled substances. Prescription medications, such as antibiotics, require oversight from a licensed healthcare...
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一个联合潜伏类贝叶斯模型,适用于所有维护研究.

Damitri Kundu1,2, Sevantee Basu1, Manash Pratim Gogoi3

  • 1Statistical Science Division, Indian Statistical Institute, Kolkata, India.

Journal of applied statistics
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PubMed
概括

这项研究引入了一种新的贝叶斯模型来分析儿童急性淋巴细胞白血病 (ALL) 治疗数据. 该模型识别了不同的患者群体,揭示了有效的儿科癌症研究非复发概率的显著差异.

关键词:
急性淋巴细胞白血病 (ALL)美国MCMCMCMCMCMCMCMC联合建模 联合建模隐藏类模型模型中的隐藏类模型.纵向结果 纵向结果

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科学领域:

  • 生物统计学 生物统计学
  • 儿科瘤学 儿科瘤学
  • 计算生物学 计算生物学

背景情况:

  • 在全球范围内,急性淋巴细胞白血病 (ALL) 仍然是儿童癌症死亡的主要原因.
  • 在发达国家,ALL的存活率有所提高,但在发展中国家却落后.
  • 临床试验需要先进的统计模型来分析复杂的纵向生物标记数据.

研究的目的:

  • 开发和验证一个联合潜伏类贝叶斯模型,用于分析儿科ALL患者数据.
  • 研究纵向生物标志物与ALL治疗结果之间的关系.
  • 根据淋巴细胞计数轨迹识别不同的患者子组.

主要方法:

  • 一个联合潜伏类贝叶斯模型,整合了纵向生物标志物 (淋巴细胞,中性粒细胞,血小板数) 和时间到事件数据.
  • 淋巴细胞计数的潜在类型建模,其他生物标志物的线性混合模型.
  • 时间到事件的半参数比例危险模型,通过共享的高斯随机效应联系在一起.

主要成果:

  • 拟议的模型确定了儿科ALL患者的淋巴细胞计数的两个不同的潜在类别.
  • 在研究期间,观察到类别特定的非复发概率的显著差异.
  • 通过模拟,联合模型与传统方法相比,显示出更高的准确性和实际实用性.

结论:

  • 联合潜伏类贝叶斯模型为分析复杂的ALL数据提供了一个强大的工具.
  • 识别不同的患者亚组可以导致个性化治疗策略和改善结果.
  • 这种方法为儿科癌症研究提供了宝贵的见解,特别是在资源有限的环境中.