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Updated: Jul 1, 2025

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域泛化使单细胞和空间转录组学中的一般癌细胞注释成为可能

Zhixing Zhong1,2, Junchen Hou3, Zhixian Yao2

  • 1Institute of Artificial Intelligence, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361102, China.

Nature communications
|March 2, 2024
PubMed
概括

癌症寻找器是一种新的深度学习算法,可以在单细胞和空间转录基因数据中准确识别恶性细胞. 该工具通过改善恶性细胞注释来增强癌症研究,以更好地了解疾病和患者预后.

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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