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Updated: Jul 1, 2025

Examination of Thymic Positive and Negative Selection by Flow Cytometry
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Published on: October 8, 2012

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通过新抗原特异性TCR进行自我歧视的结构基础.

John P Finnigan1,2,3,4, Jenna H Newman1,2,3, Yury Patskovsky5,6

  • 1Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Pl., New York, NY, USA.

Nature communications
|March 8, 2024
PubMed
概括

瘤新抗原 (neoAgs) 被T细胞受体 (TCR) 识别以杀死癌细胞. 这项研究揭示了特定突变如何增强新Ag呈现和TCR结合,改善抗瘤免疫力.

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
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