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Updated: Jul 1, 2025

Analysis of Endocytic Uptake and Retrograde Transport to the Trans-Golgi Network Using Functionalized Nanobodies in Cultured Cells
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p24-Tango1相互作用确保了ER-Golgi接口的稳定性和高效的运输效率

Ke Yang1, Zhi Feng1, José Carlos Pastor-Pareja1,2,3

  • 1School of Life Sciences, Tsinghua University , Beijing, China.

The Journal of cell biology
|March 12, 2024
PubMed
概括

蛋白质p24家族对于果的分泌至关重要. 它们在ER-Golgi接口的局部化和与Tango1蛋白的相互作用调节了囊泡运输.

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Tail-anchoring of Proteins in the ER Membrane

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Translocation of proteins across membranes is an ancient process that occurs even in bacteria and archaebacteria. In fact, the components of the translocation machinery are still conserved between prokaryotes and eukaryotes.
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While it is unclear how molecules move between adjacent Golgi cisternae, it is apparent that the molecules move from cis- cisterna, the entry face, to the trans- cisterna, the exit face. Experiments initially suggested vesicles that bud from one cisterna and fuse with the next cisterna to transport proteins between the cisternae. This vesicular transport model describes the Golgi apparatus as a relatively static structure with a unique enzyme composition in each cisterna. Molecules are...
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Golgi matrix proteins are a group of highly dynamic proteins that maintain the stacked structure of Golgi. These proteins adapt to rapid morphological changes of the Golgi during the cell cycle. During cell division, mild proteolysis removes these connections resulting in Golgi unstacking. In The daughter cells, these proteins help reassemble the unstacked Golgi.
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