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相关概念视频

Cells and Secretions of the Pancreas01:16

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The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
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The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
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High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds
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KSRP可以改善胰腺β细胞功能和生存率.

Leticia Barssotti1, Gabriela Moreira Soares1, Emílio Marconato-Júnior1

  • 1Obesity and Comorbidities Research Center (OCRC), Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, 13083864, Brazil.

Scientific reports
|March 14, 2024
PubMed
概括

KH型拼接调节蛋白 (KSRP) 对于胰腺β细胞健康至关重要. 降低KSRP水平会恶化β细胞功能障碍和胰岛素分泌,这表明KSRP是2型糖尿病的治疗点.

关键词:
细胞死亡 细胞死亡压力ERER压力ERER压力胰岛素分泌的胰岛素分泌.在KSRP中,它是KSRP.胰腺β细胞是胰腺β细胞.

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科学领域:

  • 细胞生物学 细胞生物学
  • 内分泌学 在内分泌学.
  • 分子生物学分子生物学

背景情况:

  • 胰腺β细胞功能障碍是2型糖尿病 (T2D) 的基础.
  • 识别调节β细胞应激反应的新型蛋白质对于治疗开发至关重要.
  • KH型拼接调节蛋白 (KSRP) 影响基因表达,但其在β细胞中的作用尚不清楚.

研究的目的:

  • 调查KSRP在胰腺β细胞功能和压力下生存中的作用.
  • 为了确定KSRP表达是否在β细胞功能障碍模型中发生变化.

主要方法:

  • 从饮食诱导的肥胖小鼠的胰腺小岛中评估KSRP表达.
  • 利用暴露于压力因素 (棕酸盐,CPA) 的INS-1E细胞来模拟β细胞功能障碍.
  • 在β细胞中进行了KSRP淘汰和过度表达实验.

主要成果:

  • 在所有测试的β细胞功能障碍模型中,KSRP表达减少.
  • 导致β细胞死亡增加和胰岛素分泌受损.
  • 过度表达KSRP可以保护β细胞免于死亡,并增强胰岛素分泌.

结论:

  • 在胰腺β细胞中,KSRP起着保护作用.
  • KSRP是一种潜在的治疗点,可以保护β细胞功能,预防2型糖尿病.