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相关概念视频

Types of Genetic Transfer Between Organisms02:18

Types of Genetic Transfer Between Organisms

27.8K
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
27.8K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

8.0K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
8.0K
Gene Duplication and Divergence02:37

Gene Duplication and Divergence

6.1K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
6.1K
The Central Dogma01:20

The Central Dogma

21.7K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
21.7K
Gene Conversion02:08

Gene Conversion

9.7K
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
9.7K
Viral Recombination00:57

Viral Recombination

23.4K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
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相关实验视频

Updated: Jun 29, 2025

Detection of Horizontal Gene Transfer Mediated by Natural Conjugative Plasmids in E. coli
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Detection of Horizontal Gene Transfer Mediated by Natural Conjugative Plasmids in E. coli

Published on: March 24, 2023

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使用水平基因转移编程动态分工.

Grayson S Hamrick1,2,3, Rohan Maddamsetti1,2, Hye-In Son1,2

  • 1Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, United States.

ACS synthetic biology
|April 3, 2024
PubMed
概括
此摘要是机器生成的。

动态分工 (DDOL) 使强大的微生物群落能够维持复杂的代谢途径. 这种通过横向基因转移 (HGT) 介导的策略克服了生物制造应用传统分工的局限性.

关键词:
生物制造 生物制造 生物制造劳动的分工工作.横向基因转移是指水平基因转移.代谢工程是代谢工程.微生物联盟 微生物联盟自然产品的生物合成.

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Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus
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Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus

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Automated Robotic Liquid Handling Assembly of Modular DNA Devices

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相关实验视频

Last Updated: Jun 29, 2025

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科学领域:

  • 微生物代谢工程微生物代谢工程
  • 合成生物学 合成生物学
  • 系统生物学 系统生物学

背景情况:

  • 微生物的代谢工程在生物制造,生物处理和环境修复方面提供了应用.
  • 复杂的代谢途径给宿主细胞带来了很大的代谢负担,限制了效率和生物量.
  • 目前的分工 (DOL) 策略面临着由于竞争和人口动态而维持不同的亚群体的挑战.

研究的目的:

  • 引入和定义动态分工 (DDOL) 作为一种克服维护复杂代谢途径的局限性策略.
  • 通过建模来证明,DDOL可以使繁重的多步行路径能够进行稳健的维护.
  • 研究横向基因转移 (HGT) 在调解DDOL中的作用及其在自然微生物群落中的流行情况.

主要方法:

  • 计算建模模拟和分析动态分工 (DDOL) 动态.
  • 等离子体基因组学用于识别自然微生物群落中DDOL的证据.
  • 开发用于利用HGT稳定合成代谢途径的理论框架.

主要成果:

  • 建模表明,DDOL涉及随意群体之间的动态和可逆交换,克服了传统DOL的局限性.
  • 横向基因转移 (HGT) 被提出作为一种调解DDOL的机制.
  • 基因组分析提供了证据,表明DDOL是自然微生物群落采用的策略.

结论:

  • 在微生物群落中,DDOL为维持复杂的合成代谢途径提供了强大的解决方案.
  • 生物工程师可以利用HGT来稳定工程代谢途径,提高系统的稳定性.
  • 这种方法有助于开发可靠的工程微生物系统,用于各种应用.