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针对性生物降解的近红外光纳米粒子用于结肠直肠癌成像.

Seock-Jin Chung¹, Kay Hadrick¹, Md Nafiujjaman¹

¹Department of Biomedical Engineering, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan 48824, United States.

ACS applied bio materials

|April 4, 2024

概括

新的近红外光化纳米颗粒 (FSN) 向癌胚抗原 (CEA),通过提高成像灵敏度和特异性来提高结直肠癌 (CRC) 的早期检测.

关键词:

可生物降解,可生物降解.癌胚抗原是一种癌胚抗原.结肠直肠癌是什么意思接近红外线的近红外线纳米颗粒的二氧化.

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科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

结肠直肠癌 (CRC) 是癌症死亡的主要原因,需要改进早期检测方法.
目前的诊断技术难以快速识别早期病变,平面瘤和精确的边缘划分.
光内镜提供了增强可视化的潜力,但需要提高信号强度和特异性.

研究的目的:

开发针对性的近红外 (NIR) 光氧化纳米颗粒 (FSN) 以改善早期结直肠癌 (CRC) 检测.
用抗癌胚胎抗原 (CEA) 的抗体来功能化FSN,用于分子向.
评估CEA-FSNs在CRC成像中的试验室和体内疗效.

主要方法:

合成和特征CEA向FSN (50-200nm) 具有优化的物理化学和生物降解性质.
在体外使用CEA阳性 (HT29) 和CEA阴性 (HCT116) 细胞系进行了验证的分子向.
在Xenografted小鼠和F344-PIRC老鼠的体内性能评估,分别使用静脉和局部给药.

主要成果:

与CEA阴性HCT116细胞相比,CEA-FSN显示CEA阳性HT29细胞的结合和内化优于CEA阴性HCT116细胞.
较小的CEA-FSN在HT29细胞中表现出更有效的内部化.
在CEA-FSN应用后,从小鼠的CEA阳性瘤和大鼠的肠息肉中检测到显著更高的NIR光信号.

结论:

CEA-FSN表现出特定的分子向和对结直肠癌的增强信号检测.
这些纳米颗粒显示出作为一种新型分子成像剂的承诺,用于早期CRC诊断.
进一步开发可以提高光引导内镜的灵敏度和特异性.