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检查自闭症遗传性的性别差异
Sven Sandin1,2,3, Benjamin H K Yip1,4, Weiyao Yin1
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
JAMA psychiatry
|April 17, 2024
概括
自闭症谱系障碍 (ASD) 的遗传性在男性 (87%) 比女性 (75.7%) 高. 这些发现表明,遗传差异有助于ASD性别比例差异.
科学领域:
- 遗传学 是一个遗传学.
- 神经发育障碍 神经发育障碍
- 流行病学 流行病学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种神经发育障碍,在男性中患病率较高.
- 自闭症的遗传基础及其扭曲的性别比仍然不完全理解.
- 缺乏基于人口的大规模研究,估计ASD的性别特异性遗传性.
研究的目的:
- 估计自闭症谱系障碍 (ASD) 的性别特异性遗传性.
主要方法:
- 瑞典国家卫生登记册的以人口为基础的回顾性分析.
- 包括1985年至1998年间出生的非双胞胎兄弟姐妹和表兄弟姐妹,追踪到19岁.
- 模型估计了由于性别特异性添加遗传学和环境因素导致的自闭症风险差异.
主要成果:
- 这项研究分析了456,832个家庭的1,047,649个人.
- 据估计,ASD遗传率在男性中为87.0%,在女性中为75.7%,显著差异为11.3%.
- 没有证据支持共享环境对ASD风险的贡献.
结论:
- 在ASD中表型变异的遗传性在男性和女性之间有显著差异.
- 自闭症的潜在原因可能在性别之间有所不同,这可能解释了性别比例的偏差.
- 性别之间遗传变异的差异可能部分解释了ASD观察到的性别比率.
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