压力轴向下调节:生活在当下,同时为未来做准备
Vincent A Viblanc1, Sylvia Pardonnet1, Anouch Tamian1
1Université de Strasbourg, CNRS, IPHC UMR 7178, F-67000 Strasbourg, France.
General and comparative endocrinology
|April 30, 2024
概括
哥伦比亚地松鼠的葡萄糖皮质激素 (GC) 应激激素反应较慢,并且在两性之间存在差异. 急性压力导致氧化损伤,但这与GC水平无关,表明复杂的应激反应.
科学领域:
- 比较生理学比较生理学
- 脊椎动物应激反应的压力反应
- 野生动物内分泌学 野生动物内分泌学
背景情况:
- 葡萄糖皮质激素 (GC) 是脊椎动物应激生理学和适应环境变化的关键指标.
- GC水平反映了代谢需求和应对能力,但根据个体特征和生命史阶段而有所不同.
- 评估动物压力需要将GC测量与下游指标 (如氧化压力) 的整合.
研究的目的:
- 为了研究野生哥伦比亚地松鼠的血液皮质醇和氧化应激标志物,按照标准化的捕获处理应激因子.
- 为了比较生殖后的雄性和6月中旬至6月下旬断子的雌性压力反应.
- 探索激素应激反应和氧化损伤标志物之间的关系.
主要方法:
- 野生成年哥伦比亚地松鼠 (Urocitellus columbianus) 经历了30分钟的捕获处理压力.
- 收集血液样本以测量皮质醇水平和氧化应激标志物 (损伤和防御).
- 在特定的生命史阶段进行了测量:雄性准备冬眠,雌性断幼.
主要成果:
- 地松鼠的GC增加的时间过程明显比大多数其他脊椎动物报告的要慢.
- 哺乳期的雌性表现出淡的GC反应,而后生殖期的雄性表现出反应.
- 短期压力诱导了轻度至中度的氧化损伤和氧化防御的减少,独立于GC变化.
结论:
- 与其他物种相比,哥伦比亚地松鼠表现出独特的,缓慢起作用的荷尔蒙应激反应.
- 生命史阶段对这种物种的内分泌应激反应产生了重大影响.
- 在急性荷尔蒙应激反应和由此产生的氧化损伤之间存在分离,表明复杂的生理权衡.
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