在肺癌CT查中发现的甲状腺异常
Maaike van Gerwen1, Teng Ma2, Rowena Yip3
1Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
偶然的甲状腺结节 (ITN) 在肺癌查CT扫描中很常见. 在这些结节中没有发现恶性瘤,尽管在女性中发现了乳腺密度等预测因素.
科学领域:
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 偶然的甲状腺结节 (ITNs) 经常在低剂量计算机断层扫描 (LDCT) 中作为肺外发现,用于肺癌查.
- 了解ITN的患病率,特征和恶性瘤潜力对于有效的患者管理和减少不必要的随访至关重要.
研究的目的:
- 在基线上确定ITN的频率并重复LDCT扫描.
- 为了评估偶然检测到的甲状腺结节的恶性瘤率.
- 确定与ITN相关的人口,临床和CT相关的预测因素.
主要方法:
- 在MS-ELCAP LDCT肺部查计划 (2010-2016) 中对2309名参与者的回顾性分析.
- 在基线和每年重复的LDCT扫描上评估ITN频率.
- 多变量回归分析以确定ITN的重要预测因素.
主要成果:
- 在基线时,在2.5%的参与者中检测到ITN,并在每年重复扫描时检测到0.15%.
- 新发现的ITN很小 (<15毫米),表明增长缓慢.
- 在女性中,增加年龄,冠状动脉化和乳腺密度是ITN的显著预测因素;对于男性,没有发现预测因素.
结论:
- 在肺癌查的LDCT扫描中通常检测到ITN,但恶性瘤很少见.
- 女性中ITN的预测因素,如乳腺密度,表明潜在的共同病因因素.
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