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相关概念视频

Overview of Exosomes01:36

Overview of Exosomes

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Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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相关实验视频

Updated: Jun 27, 2025

Evaluation of the Storage Stability of Extracellular Vesicles
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来自Treg的细胞外囊泡:在疾病和治疗术中的作用

Tingting Wu1,2, Lulu Wang1,2, Chen Gao1,2

  • 1Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Molecular pharmaceutics
|May 2, 2024
PubMed
概括

调节性T细胞 (Tregs) 和它们的细胞外囊泡 (Treg-EVs) 对于免疫耐受性至关重要. 这篇评论探讨了Treg-EVs.

关键词:
外基因组是外基因组的组成部分.细胞外囊泡中的细胞外囊泡.微小的微小的微小的微小的微小监管T细胞的监管性T细胞他们是天文学家.

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Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
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In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
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相关实验视频

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Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
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科学领域:

  • 免疫学和细胞生物学
  • 细胞外囊泡研究研究
  • 热门节目 热门节目 热门节目

背景情况:

  • 调控性T细胞 (Tregs) 是CD4+T细胞的一个子集,对于免疫自我耐受性和治疗应用至关重要.
  • 由Treg衍生的细胞外囊泡 (Treg-EVs) 已因其在Treg细胞功能中的重要作用而得到认可.
  • 细胞外囊泡 (EVs) 是细胞衍生的颗粒,携带具有异能潜力的生物活性分子.

研究的目的:

  • 综合审查Treg-EVs中的分类和活性分子.
  • 探索Treg-EV在各种疾病环境中的多样化应用.
  • 为了确定基于Treg-EV的天文学的当前挑战和未来前景.

主要方法:

  • 文献综述侧重于Treg-EV分类,分子载荷和治疗应用.
  • 对Treg-EVs参与生理和病理过程的分析.
  • 对Treg-EV用于疾病治疗的现有研究的评估.

主要成果:

  • Treg-EVs含有来自母Treg细胞遗传的蛋白质和miRNAs.
  • Treg-EVs涉及许多生理和病理机制.
  • 对于Treg-EVs在疾病治疗和诊断 (theranostics) 中存在显著的潜力.

结论:

  • 由于它们的生物活性载荷,Treg-EVs代表了用于theranostic应用的有希望的平台.
  • 需要进一步的研究来克服Treg-EV隔离,表征和临床翻译方面的挑战.
  • 这次审查澄清了Treg-EV的可行性和潜力,鼓励未来的发展.