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Analgesia and Pain Management01:25

Analgesia and Pain Management

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Role of Cerebellum and Prefrontal Cortex in Memory01:14

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The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
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Updated: Jun 27, 2025

Intracranial Pharmacotherapy and Pain Assays in Rodents
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在疼痛中准前额叶皮层功能障碍

Kai Kummer1, Patrick L Sheets2

  • 1Institute of Physiology, Medical University of Innsbruck, Innsbruck, Austria (K.K.); Department of Pharmacology and Toxicology (P.L.S.), Medical Neurosciences Graduate Program (P.L.S.), and Stark Neurosciences Research Institute (P.L.S.), Indiana University School of Medicine, Indianapolis, Indiana.

The Journal of pharmacology and experimental therapeutics
|May 3, 2024
PubMed
概括
此摘要是机器生成的。

慢性疼痛会破坏前额叶皮层 (PFC),影响情绪和认知. 准PFC为慢性疼痛及其相关疾病提供了新的治疗策略.

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科学领域:

  • 神经科学是一个神经科学.
  • 疼痛研究 疼痛研究
  • 精神病学是一个精神病学.

背景情况:

  • 前额叶皮层 (PFC) 越来越多地被认为在慢性疼痛中的作用.
  • 几十年来,动物和人类的研究支持研究慢性疼痛中PFC功能障碍.
  • 慢性疼痛导致PFC的结构,化学和连接性变化.

研究的目的:

  • 审查由于慢性疼痛导致的动物和人类PFC的复杂变化.
  • 探索针对PFC的潜在药理和非药理治疗方法.
  • 突出PFC在疼痛引起的并发症,如焦虑,抑郁和认知衰退中的作用.

主要方法:

  • 关于PFC和慢性疼痛的动物和人类研究的综合文献综述.
  • 综合了PFC中结构,化学和连接性变化的发现.
  • 对针对PFC电路的现有和潜在治疗干预措施的分析.

主要成果:

  • 慢性疼痛显著改变了PFC结构,化学和两种物种的连接性.
  • PFC功能障碍与慢性疼痛及其并发症的持续性有关.
  • 有证据表明,PFC操纵可以缓解疼痛和相关的心理痛苦.

结论:

  • PFC是新型慢性疼痛治疗的关键目标.
  • 准PFC电路为开发更安全,更有效的疼痛治疗提供了一个有希望的途径.
  • 了解PFC的作用是解决更好的慢性疼痛管理和并发症治疗的未满足需求的关键.