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相关概念视频

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

94
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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中国多领域干预倡议 (CHINA-IN-MUDI) 预防认知衰退:研究设计和进展

S-Y Li1, X-Y Xie, D Liu

  • 1Yan Zeng, Brain Science and Advanced Technology Institute, School of Medicine, Wuhan University of Science and Technology, West Huangjiahu Road, Hongshan District, Wuhan 430065, China. Email: zengyan68@wust.edu.cn; Jin-Tai Yu, Department of Neurology and National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Huashan Hospital, Shanghai Medical College, Fudan University, 12th Wulumuqi Zhong Road, Shanghai 200040, China. Email: jintai_yu@fudan.edu.cn; Wei Tan, Geriatric Hospital Affiliated to Wuhan University of Science and Technology, West Huangjiahu Road, Hongshan District, Wuhan 430065, China.

The journal of prevention of Alzheimer's disease
|May 6, 2024
PubMed
概括

这项研究介绍了CHINA-IN-MUDI,一种生活方式干预措施,以防止中国的认知能力下降. 它的目的是为针对阿尔茨海默病 (AD) 的公共卫生策略提供证据.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.多领域的行为干预.多中心多中心.临床前阶段 临床前阶段随机对照临床试验是随机对照临床试验.中国健康衰老和痴呆症研究.

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科学领域:

  • 老年学与公共卫生
  • 神经科学和临床试验

背景情况:

  • 阿尔茨海默病 (AD) 构成了日益严重的全球健康挑战,预测显示到2050年,病例将大幅增加.
  • 之前在欧洲的多领域生活方式干预措施显示出对痴呆症预防的希望,但由于人口和文化差异,在中国的直接应用是有限的.
  • 现有的中国试验缺乏国家代表性,强调需要多样化的队列来准确评估早期干预的有效性.

研究的目的:

  • 开发和评估一种文化适应的,多领域的生活方式干预 (CHINA-IN-MUDI) 以预防代表性中国人口的认知衰退.
  • 在FINGER研究设计的基础上,评估中国式干预的可行性和有效性.
  • 探索实施策略,并在中国不同环境中全面评估早期多领域干预措施.

主要方法:

  • 中国多领域干预倡议 (CHINA-IN-MUDI) 是一个为期两年的多中心,开放标签,集群随机对照试验.
  • 参与者 (60-80岁) 是从中国健康衰老和痴呆研究队列中招募的,以确保国家代表性.
  • 干预计划被标准化,以与中国的文化和社会经济背景保持一致,包括基因组/蛋白质组分析和电子健康应用程序.

主要成果:

  • 查于2022年7月开始,有1965名参与者随机选择 (772名干预,1,193名控制).
  • 基线特征在各组之间相似,揭示了流行的生活方式和血管风险因素.
  • 试验正在进行中,预计将于2025年完成.

结论:

  • "中国在城市"项目将评估阿尔茨海默病 (AD) 风险降低多领域干预措施的有效性和安全性.
  • 调查结果将为中国的公共卫生决策提供有关痴呆症预防策略的信息.
  • 这项研究为在不同人群中实施和调整生活方式干预措施以促进认知健康提供了基础.