降低对甲状腺激素的敏感性与 euthyroid 个体的肺功能有关.
Zhaoxiang Wang1, Bing Lu1, Menghuan Wu2
1Department of Endocrinology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, 215300, China.
降低甲状腺激素敏感性与无甲状腺患者的肺功能受损有关. 较高的甲状腺反量基指数 (TFQI) 和较低的自由三甲状腺素/自由甲状腺素 (FT3/FT4) 比率表明阻塞性和限制性肺病的风险增加.
科学领域:
- 内分泌学 在内分泌学.
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 甲状腺和肺部之间有着复杂的关系.
- 甲状腺激素敏感性对无甲状腺患者肺功能的影响需要进一步调查.
研究的目的:
- 探索甲状腺激素敏感性和肺功能之间的相关性.
- 评估甲状腺激素敏感性作为阻塞性和限制性肺病的风险因素.
- 调查甲状腺反量基指数 (TFQI) 和全因死亡率之间的关联.
主要方法:
- 使用了来自国家健康和营养检查调查 (NHANES) 数据库的螺旋计和死亡率数据.
- 根据FEV1/FVC比率和预测的FVC,定义了阻塞和限制性肺功能.
- 使用TFQI和FT3/FT4比率评估中部和外围甲状腺激素敏感性,使用后勤回归和子组分析.
主要成果:
- 分析了6,539名参与者,确定900名患有阻塞性肺功能和407名患有限制性肺功能.
- 发现肺功能受损的患病率增加,TFQI水平更高.
- 证明增加TFQI和降低FT3/FT4比率是阻塞性和限制性肺功能 (p <0.05) 的独立风险因素.
- TFQI成为所有原因死亡率的独立风险因素 (HR=1.25,p=0.048).
结论:
- 降低甲状腺激素敏感性与肺功能受损有关.
- TFQI和FT3 / FT4比率作为有价值的流行病学工具来量化甲状腺抵抗在肺功能.
- 甲状腺激素敏感性是肺部健康和整体死亡风险的重要因素.
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