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Updated: May 5, 2026

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
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创建一个更具战略性的小分子生物物理命中表征工作流程.

Christopher Fotsch1, Debaleena Basu2, Ryan Case2

  • 1Lead Discovery and Characterization Group, Amgen Research, Thousand Oaks CA, USA.

SLAS discovery : advancing life sciences R & D
|May 9, 2024
PubMed
概括

使用热转移试验 (TSA) 之后使用表面等离子体共振 (SPR) 或与温度相关的强度变化 (TRIC) 试验的新工作流改善了击中质量. 生物物理确认的命中证明了比未确认的命中更好的药物相似性和溶解性.

关键词:
击中特征的描述.击败质量 击败质量击中分类的分类.目标参与度 目标参与度

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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