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相关概念视频

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Hybridoma Technology01:31

Hybridoma Technology

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
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相关实验视频

Updated: Jun 26, 2025

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

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SEMA 2.0:使用人工智能预测B细胞形状表征的网络平台.

Nikita V Ivanisenko1,2, Tatiana I Shashkova1, Andrey Shevtsov1,3

  • 1Bioinformatics Group, AIRI, Moscow, Russia.

Nucleic acids research
|May 14, 2024
PubMed
概括

SEMA 2.0是一个新的网络平台,用于预测B细胞表位,帮助疫苗设计. 它使用先进的蛋白质语言模型进行序列和结构分析,增强免疫性研究.

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Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
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Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope

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Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell Populations
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Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell Populations

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相关实验视频

Last Updated: Jun 26, 2025

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07:59

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

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Peptide Scanning-assisted Identification of a Monoclonal Antibody-recognized Linear B-cell Epitope
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Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell Populations
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科学领域:

  • 免疫信息学是指免疫信息学.
  • 计算型疫苗学 计算型疫苗学
  • 结构生物学是结构生物学.

背景情况:

  • 符合性B细胞表位预测对于有效的疫苗设计至关重要.
  • 准确的预测有助于理解抗原-抗体相互作用和免疫反应.

研究的目的:

  • 推出SEMA 2.0,一个用户友好的网络平台,用于B细胞表位预测.
  • 为基于序列和结构的表位分析和N-糖基化位点识别提供工具.
  • 为了便于对抗原B细胞表皮结构进行免疫性评估的比较.

主要方法:

  • 使用最先进的蛋白质语言模型进行表位预测.
  • 集成基于序列和结构的预测方法.
  • 包括一个模块来比较B细胞表皮质结构.

主要成果:

  • SEMA 2.0 提供了用于B细胞表位预测的全面工具.
  • 该平台准确地识别了N-糖化位.
  • 一个新的模块允许对表观物进行比较结构分析.

结论:

  • SEMA 2.0增强了研究人员的B细胞表位预测能力.
  • 该平台支持疫苗设计和免疫性研究.
  • SEMA 2.0 在线免费访问,源代码可用.