从临床样本中,与主观认知衰退相关的结构神经成像变化.
Mario Riverol1, Mirla M Ríos-Rivera2, Laura Imaz-Aguayo3
1Department of Neurology, Clínica Universidad de Navarra, Pamplona 31008, Navarra, Spain; Instituto de Investigación Sanitaria de Navarra, Pamplona 31008, Navarra, Spain.
NeuroImage. Clinical
|May 15, 2024
概括
患有主观认知衰退 (SCD) 的个体在前脑叶和后脑叶出现早期脑缩. 那些进展为阿尔茨海默氏病 (AD) 的人也表现出中叶缩,表明通过MRI进行潜在的早期诊断.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 阿尔茨海默病 (AD) 涉及渐进性的认知能力下降.
- 主观认知衰退 (SCD) 可以先于AD.
- 在SCD中神经成像已经产生了异质的结果.
研究的目的:
- 为了确定与对照人群相比,SCD患者的形态大脑差异.
- 调查SCD患者的基线结构变化,这些人保持稳定,与那些进展的人相比.
主要方法:
- 309名SCD参与者和43名健康对照 (HCs) 接受了基线MRI.
- 基于voxel的形态学 (VBM) 和兴趣区域 (ROI) 分析评估了灰色和白质体积.
- XTRACT ATLAS发现了白质道损伤.
主要成果:
- SCD组表现出前额叶和后额叶的灰质缩,以及几个区域的白质体积减少.
- 进展性SCD (SCDp) 个体表现出比稳定的SCD (SCDnp) 和HC组更大的海马缩.
- 在SCD和HC组之间没有发现白质病变负担的显著差异.
结论:
- SCD与前额叶和后额叶的早期缩有关.
- 基线时中叶缩是从SCD进展的个体特有的.
- 连接的结构性脑损伤可能是AD连续体中早期记忆力下降的基础.
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