丸激素和红细胞的寿命
Melissa C McMartin1, Sasha Savkovic2, Adelina Romano1
1ANZAC Research Institute, University of Sydney, Concord Repatriation General Hospital, Concord Hospital, Sydney, NSW 2139, Australia.
The Journal of clinical endocrinology and metabolism
|June 24, 2024
概括
雄激素急剧增加红细胞的寿命在阴腺男性,但长期影响红细胞寿命和血红蛋白需要进一步研究. 这项研究探讨了雄激素对红细胞寿命的影响.
科学领域:
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
- 生理学 生理学 生理学
背景情况:
- 众所周知,雄激素会增加红细胞和血红蛋白水平.
- 雄激素对红细胞寿命的影响仍然在很大程度上是未知的.
- 研究雄激素对红细胞寿命的影响对于理解它们更广泛的生理影响至关重要.
研究的目的:
- 确定雄激素对人类和小鼠未成熟和成熟红细胞寿命的影响.
- 利用新的,最少侵入性的,非放射性方法来评估红细胞寿命.
- 阐明雄激素受体在调节红细胞寿命中的作用.
主要方法:
- 在接受丸激素治疗的阴阴腺/变性男性中,使用莱维特公式 (膜一氧化碳和血红蛋白水平) 评估了人类红细胞寿命.
- 鼠标红细胞寿命使用体内生物标记和流动细胞计量来测量红细胞和网细胞在接受雄激素治疗或受体失活后的红细胞和网细胞数量.
- 特定标记物 (Ter119,CD71,CD45) 用于在小鼠中识别和量化网状细胞和红细胞.
主要成果:
- 在接受丸激素治疗之前,低腺体和变性男性的红细胞寿命减少.
- 丸激素治疗在6周后暂时增加了人类的红细胞寿命,在18周后恢复到基线,尽管丸激素和血红蛋白持续增加.
- 在小鼠中,雄激素治疗增加了红细胞寿命,但没有显著影响状细胞寿命;雄激素受体淘汰或状细胞切除并没有改变红细胞或状细胞寿命.
结论:
- 低阴腺男性的红细胞寿命有所减少.
- 在雄激素的使用后,红细胞寿命的急剧增加可能会导致它们已知的红细胞生成效应.
- 需要进一步的研究来确定雄激素对循环中的血红蛋白水平增加的长期贡献.
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