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Updated: Jun 23, 2025

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使用深度学习来划分酵母分裂和多化信号

Emily Kunce Stroup1, Zhe Ji2,3

  • 1Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

Genome research
|June 24, 2024
PubMed
概括

深度学习模型揭示了酵母mRNA成熟过程中退化的多基化信号. 这些模型揭示了Saccharomyces cerevisiae和Schizosaccharomyces pombe中不同的调节元素,从而改善了对裂变和多化的理解.

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Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
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