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一个模块化的512通道神经信号采集ASIC用于高密度4096通道电生理学.

Aikaterini Papadopoulou1, John Hermiz1, Carl Grace1

  • 1Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

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概括

我们开发了一种可扩展的,超低噪音的512通道神经记录电路,用于高分辨率的大脑活动监测. 这种灵活的模块可以实现密集的电极集成,用于先进的神经科学研究.

科学领域:

  • 神经科学是一个神经科学.
  • 电气工程 电气工程
  • 生物医学工程 生物医学工程

背景情况:

  • 大脑的信息处理需要高的空间和时间分辨率.
  • 密集的电极阵列和高通道计数电子对于先进的神经记录至关重要.
  • 现有技术在可扩展性和噪声性能方面面临限制.

研究的目的:

  • 开发一种超低噪音,可扩展的神经记录电路.
  • 为了创建一个灵活的,高通道计数模块用于脑-计算机接口.
  • 为了证明体内神经信号采集的能力.

主要方法:

  • 设计了一种512通道的神经读取应用特定集成电路 (ASIC),具有2D布局.
  • 使用TSMC 0.18微米1.8伏CMOS技术制造了芯片.
  • 将ASIC集成到一个超轻,灵活的模块中,具有可编程模拟前端和14位ADC.

主要成果:

  • 通过512个同时录制通道实现了超低噪声性能,可扩展到4096.6.
  • 展示了一种灵活,轻量级的模块 (350毫克),适合小型动物头部.
  • 在体内成功记录神经信号,包括尖峰和场电位.
关键词:
生物医学电子产品生物潜能记录记录大脑 机器界面在前端的电路中.高频道计数高频道计数在活体中,活体中神经读数的读取结果

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结论:

  • 开发的神经记录电路为密集的神经接口提供了可扩展和高性能解决方案.
  • 灵活的模块通过实现高分辨率的大脑活动监测,促进了先进的神经科学研究.
  • 该技术在需要精确测量神经动态的应用中显示出前景.