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工程微型 IscB 尼卡斯,用于强大的基础编辑,具有广泛的准范围

Linxiao Han1, Yueer Hu1, Qiqin Mo1

  • 1Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai, China.

Nature chemical biology
|July 8, 2024
PubMed
概括

研究人员从IscB设计了微型基因编辑器IminiBEs,以实现高效的基因组编辑. 融合Sso7d蛋白质创造了SIminiBEs,进一步提高了编辑效率,并扩大了对精确基因修改的目标识别.

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