补体系统分子:在猪怀孕期间在母体 - 孕胎界面的表达和调节
Soohyung Lee1, Inkyu Yoo1, Yugyeong Cheon1
1Division of Biological Science and Technology, Yonsei University, Wonju, 26493, Republic of Korea.
Developmental and comparative immunology
|July 14, 2024
概括
补体系统对于天生的免疫力至关重要. 这项研究揭示了它在猪怀孕中的关键作用,影响孕产妇免疫调节,使孕期成功.
科学领域:
- 生殖免疫学 生殖免疫学
- 这是天生的免疫力.
- 补充系统生物学
背景情况:
- 补体系统对于天生的免疫力至关重要.
- 它的失调与人类和动物的不良妊娠结果有关.
- 它在母婴接口的猪中的作用仍未得到研究.
研究的目的:
- 研究猪在母体 - 孕胎界面上的补充系统分子的表达,定位和调节.
- 了解补体系统在猪怀孕的建立和维持中的作用.
主要方法:
- 在子宫内膜,概念体和胆组织组织中研究补充成分和控制蛋白的表达和局部化.
- 分析了与雌激周期相比,怀孕期间表达的变化.
- 在子宫内膜扩展体中通过干扰素- (IFNG) 检查的调节.
- 在组织和子宫冲洗中检测到裂开的C3碎片.
主要成果:
- 补充分子表达在猪的母体 - 孕妇接口组织中.
- 早期补体激活剂的表达在怀孕期间在子宫内膜增加.
- 观察到补充蛋白的细胞类型特定定位.
- 干扰素-玛上调了特定的补充基因.
- 怀孕期间发现C3碎片分离的水平增加.
结论:
- 补体系统分子存在于猪的母体 - 胎儿界面,并受到调节.
- 这些分子可能在天生的免疫力中发挥重要作用,并在怀孕期间调节母亲的免疫环境.
- 结果表明在猪的怀孕建立和维持方面发挥了作用.
相关概念视频
01:15Transcytosis of IgG
2.7K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.7K
01:22Development of Immunocompetence
300
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
300