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Updated: Jun 18, 2025

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
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NMDtxDB:对人类NMD目标转录的数据驱动识别和注释

Thiago Britto-Borges1,2, Niels H Gehring3,4, Volker Boehm3,4

  • 1Section of Bioinformatics and Systems Cardiology, Department of Internal Medicine III and Klaus Tschira Institute for Integrative Computational Cardiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.

RNA (New York, N.Y.)
|August 2, 2024
PubMed
概括

这项研究引入了一种数据驱动的方法,用于识别无意义介导RNA衰变 (NMD) 目标转录. NMDtxDB数据库提供了一个全面的资源,用于研究NMD敏感RNA及其调节.

关键词:
替代性拼接是一种替代性的拼接.计算工作流的计算工作流.在mRNA衰变过程中.无意义介导的RNA衰变过早停止 codon 的时间.

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相关概念视频

Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
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