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C9orf72 聚PR 与核孔复合体的相互作用

Hamidreza Jafarinia1, Erik Van der Giessen1, Patrick R Onck1

  • 1Zernike Institute for Advanced Materials, University of Groningen, Groningen, the Netherlands.

Biophysical journal
|August 29, 2024
PubMed
概括

在ALS/FTD中有毒的聚烯-阿基因 (PR) 不会在核孔复合体 (NPC) 中聚合. 相反,PR通过NPC转移,转移难度随着PR长度的增加而增加.

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