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通过选择最适合RAAV优化设计来释放DOE的潜力.

Konstantina Tzimou1, David Catalán-Tatjer1, Lars K Nielsen1,2

  • 1The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.

Molecular therapy. Methods & clinical development
|September 19, 2024
PubMed
概括

优化基因治疗的复合腺相关病毒 (rAAV) 生产需要仔细平衡等离子体度. 混合设计 (MD) 与面中心中心复合设计 (FCCD) 结合,显著提高了体积生产率.

关键词:
在 AAV AAV AAV 中.一个盒子-Behnkenken.美国能源部负责人生物制造 生物制造 生物制造设计实验的设计.基因治疗的基因疗法混合物设计 混合物设计优化的优化优化优化.再组合腺相关病毒.响应表面方法的方法.

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