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Updated: May 15, 2026

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
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Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

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从单细胞转录组学来解码疟疾药物点的计算方法,并找到潜在的药物分子.

Soham Choudhuri1, Bhaswar Ghosh2

  • 1Center for Computational Natural Sciences and Bioinformatics, International Institute of Information Technology, Hyderabad, 500032, India.

Scientific reports
|October 14, 2024
PubMed
概括

疟疾寄生虫的耐药性需要新的治疗方法. 这项研究使用机器学习对Plasmodium falciparum的转录数据来识别药物点,并通过计算预测具有有利性质的新型抗疟疾药物.

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Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

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相关概念视频

Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...