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使用单细胞转录组学解开HNSCC的复杂性

Cristina Conde-Lopez1, Divyasree Marripati2,3, Moshe Elkabets2,3

  • 1Division Radiooncology/Radiobiology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany.

Cancers
|October 16, 2024
PubMed
概括

单细胞RNA测序 (scRNAseq) 提供了详细的洞察头部和部状细胞癌 (HNSCC) 以及其瘤微环境. 这项技术有助于了解HNSCC的进展,诊断和治疗反应.

关键词:
在HNSCC中,我们可以看到HNSCC.一个单细胞RNA测序.瘤微环境是一个微环境.

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...