在出生时人类大脑结构的性别差异
Yumnah T Khan1,2, Alex Tsompanidis3, Marcin A Radecki3,4
1Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH, UK. yk415@cam.ac.uk.
Biology of sex differences
|October 18, 2024
概括
大脑结构的性别差异在出生时就显而易见,男性一般具有更大的整体大脑体积. 雌性表现出更多的灰质,而雄性表现出更多的白质,在发育早期存在区域差异.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 人类解剖学 人类解剖学
背景情况:
- 成年人脑部解剖学中的性别差异已经确立,但在早期发育过程中不太了解.
- 新生儿期对大脑发育至关重要,为产前和产后早期对基于性别的大脑变异的影响提供了洞察力.
研究的目的:
- 调查新生儿全球和区域大脑体积的平均性别差异.
- 检查性别与年龄之间的相互作用,以了解出生后早期大脑发育的轨迹.
主要方法:
- 利用了514名新生儿 (0-28天) 的数据,这些新生儿来自正在开发的人类连接组项目.
- 评估全球和区域大脑容量,控制出生体重和总大脑容量.
- 分析了性别与年龄之间的相互作用,以确定发育趋势.
主要成果:
- 男性平均表现出更大的内和总大脑体积.
- 在控制大脑总体体积后,女性的皮质灰质体积更大,而男性的白质体积更大.
- 观察到灰质和白质的显著区域差异,其中一些显示性别年龄相互作用.
结论:
- 大脑结构的性别差异在出生时就存在.
- 这些差异在出生后早期的发育过程中似乎相对稳定.
- 产前因素可能在确定大脑中生命早期的性别差异方面发挥着重要作用.
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