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Updated: Jun 10, 2025

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

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使用clamp-G修饰核基增强RNA抑制活性.

Sai Pallavi Pradeep1, Vikas Kumar1, Shipra Malik1

  • 1Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA.

Cell reports. Physical science
|October 18, 2024
PubMed
概括

作为微RNA和信使RNA抑制剂,clamp-G修饰核酸 (cGPNA) 是一个有前途的药物. 这些cGPNAs有效地减少了淋巴瘤模型中的瘤生长,并在体内向了transthyretin mRNA.

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