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相关概念视频

Olfaction01:25

Olfaction

44.2K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
44.2K
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

2.3K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep...
2.3K
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

376
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
376
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

8.1K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
8.1K
Association Areas of the Cortex01:21

Association Areas of the Cortex

5.1K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
5.1K
Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

3.0K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor...
3.0K

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相关实验视频

Updated: Jun 9, 2025

A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation
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A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation

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在复杂的嗅觉记忆任务中,所需的是内膜皮层,而不是前膜皮层.

Dahae J Jun1, Rebecca Shannon1, Katherine Tschida1

  • 1Department of Psychology, Cornell University, 211 Uris Hall Ithaca, NY 14853 United States.

bioRxiv : the preprint server for biology
|October 28, 2024
PubMed
概括

脑下皮层 (IL) 对于记忆控制至关重要. 抑制IL活性可以防止反向干扰,这表明它在新学习过程中抑制旧记忆的作用.

科学领域:

  • 神经科学是一个神经科学.
  • 认知科学 认知科学
  • 行为神经科学 行为神经科学

背景情况:

  • 中间前额叶皮层 (mPFC) 对记忆和行为灵活性至关重要.
  • 截然不同的分区域,前边缘 (PL) 和下边缘 (IL),在记忆检索和抑制方面提出了不同的角色.

研究的目的:

  • 研究mPFC的PL和IL亚区在解决记忆干扰方面的特定作用.
  • 为了确定IL是否参与抑制以前获得的记忆,从而干扰新的学习.

主要方法:

  • 化学遗传学 (DREADDs) 用于抑制mPFC中的神经元活动.
  • 鼠被训练在一个有条件的歧视任务与冲突的气味歧视问题 (集A和B).
  • 一个中期会话交换器在高干扰条件下测试了记忆检索,检查了PL和IL的失活.

主要成果:

  • 对照大鼠在学习了B组后显示出A组记忆的检索受损,这表明有追溯作用的干扰.
  • 与对照组相比,PL无活化没有改变性能.
  • IL无活化取消了追溯干扰效应,这表明IL在记忆抑制中起着关键作用.

结论:

  • 下边缘皮层 (IL) 在解决干扰所需的记忆控制过程中起着至关重要的作用.
关键词:
脑内膜下皮层的皮层.中部前额叶皮层中部前额叶皮层记忆检索回忆检索的方法味道记忆 味道记忆 味道记忆在前肢皮层前的皮层.

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A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation
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  • 似乎IL对于积极抑制与当前目标相冲突的先前学习的记忆的检索至关重要.