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相关概念视频

Olfaction01:25

Olfaction

44.1K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
44.1K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

7.8K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
7.8K
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

322
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
322
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

2.1K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep...
2.1K
Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

2.7K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor...
2.7K
Association Areas of the Cortex01:21

Association Areas of the Cortex

4.9K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
4.9K

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相关实验视频

Updated: May 24, 2025

A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation
10:42

A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation

Published on: August 18, 2014

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在复杂的嗅觉记忆任务中,需要下边缘皮层,而不是前边缘皮层.

Dahae J Jun1, Rebecca Shannon1, Katherine Tschida1

  • 1Department of Psychology, Cornell University, 211 Uris Hall, Ithaca, NY 14853 United States.

Neurobiology of learning and memory
|March 3, 2025
PubMed
概括

脑下皮层 (IL) 对于记忆控制至关重要,特别是抑制阻碍新学习的旧记忆. 这一发现突显了IL在解决记忆干扰方面的作用.

科学领域:

  • 神经科学是一个神经科学.
  • 认知神经科学 认知神经科学
  • 行为神经科学 行为神经科学

背景情况:

  • 中间前额叶皮层 (mPFC) 对记忆和行为灵活性至关重要.
  • 像前膜 (PL) 和下膜 (IL) 皮层这样的子区域具有不同的作用,PL促进和IL抑制反应.
  • 在高干扰时mPFC是活跃的,这表明在解决干扰时PL和IL的作用不同.

研究的目的:

  • 研究mPFC的PL和IL亚区在解决记忆干扰方面的特定作用.
  • 为了确定IL是否参与抑制以前获得的记忆,从而干扰新的记忆检索.

主要方法:

  • 化学遗传学 (DREADDs) 用于抑制mPFC中的神经元活动.
  • 鼠被训练在一个有条件的歧视任务与冲突的气味歧视问题 (集A和B).
  • 一个中期会话切换测试了高干扰条件下的记忆检索,具有特定的PL或IL区域的失活.

主要成果:

  • 对照大鼠在学习了B组后显示出A组记忆的检索受损,这表明有追溯作用的干扰.
  • 与对照组相比,PL无活化并没有显著改变性能.
  • IL无活化阻止了Set A记忆检索中的缺陷,这表明IL对于抑制干扰记忆至关重要.
关键词:
脑内膜下皮层的皮层.中部前额叶皮层中部前额叶皮层.记忆检索 记忆检索 记忆检索嗅觉记忆中的气味.临界前皮层 (prelimbic cortex) 是一个前临界皮层.

更多相关视频

Olfactory Context Dependent Memory: Direct Presentation of Odorants
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Olfactory Context Dependent Memory: Direct Presentation of Odorants

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Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
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Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

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相关实验视频

Last Updated: May 24, 2025

A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation
10:42

A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation

Published on: August 18, 2014

8.9K
Olfactory Context Dependent Memory: Direct Presentation of Odorants
04:47

Olfactory Context Dependent Memory: Direct Presentation of Odorants

Published on: September 18, 2018

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Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
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Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

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结论:

  • 下肢皮层 (IL) 在记忆控制中发挥着关键作用,通过积极抑制以前获得的,干扰记忆的检索.
  • 这些发现阐明了介质前额叶皮层内内存干扰分辨的具体神经机制.