非处方药的抗生素会影响氨基糖化物活性
A Robertson1, G Coutinho2, E Mantzourani1
1School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.
The Journal of antimicrobial chemotherapy
|October 29, 2024
概括
像格拉米西丁这样的非处方抗生素可以通过破坏细菌膜来降低必要的临床抗生素的有效性. 这种干扰有助于抗菌素耐药性 (AMR) 和潜在的治疗失败.
科学领域:
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
背景情况:
- 抗菌素耐药性 (AMR) 是一个关键的全球健康挑战.
- 非处方 (OTC) 抗生素,特别是喉炎药物,可能会导致AMR.
- 人们担心,OTC抗生素可能会诱导临床重要抗生素的交叉耐药性.
研究的目的:
- 调查三种在OTC喉疼痛药物中发现的抗生素对新出现的AMR的体外影响.
- 为了确定OTC抗生素是否会影响常用的临床抗生素的疗效.
主要方法:
- 细菌病原体被单独使用氨基甘油酸抗生素和OTC抗生素 (细素,格拉米西丁,铁素) 进行时间杀伤测试.
- 通过测量泄漏和OTC抗生素暴露后的膜潜在变化来评估膜损伤.
主要成果:
- 格拉米西丁显著降低了阿米卡辛,托布拉米辛和珍塔米辛对抗Acinetobacter baumannii的杀菌活性.
- 格拉米西丁和铁素在其他关键病原体如Enterobacter cloacae,大肠杆菌和Klebsiella pneumoniae中降低了氨基甘油酸的有效性.
- 暴露于格拉米西丁导致细菌膜潜力的显著降低和泄漏.
结论:
- 格拉米西丁和铁素通过破坏细菌膜潜能来干扰氨基甘油酸的疗效,这对于药物吸收至关重要.
- 这些发现突出了一个潜在的机制,即OTC抗生素可能导致治疗失败,并导致AMR的发展.
- 虽然同时使用可能不常见,但这项研究强调了OTC抗生素对耐药性和治疗疗效问题的可能途径.
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