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转录DB:一个以转录为中心的数据库,用于研究真核生物的转录保护和进化.

Wend Yam D D Ouedraogo1, Aida Ouangraoua1

  • 1Department of Computer Science, Faculté des sciences, Université de Sherbrooke, 2500 Boulevard de l'Université, Sherbrooke, QC J1K 2R1, Canada.

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概括
此摘要是机器生成的。

转录DB是一个新的数据库,用于研究真核生物基因家族的转录保护和进化. 它对317种物种进行了保存的转录和分谱编目,有助于理解基因和转录进化.

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科学领域:

  • 基因组学就是基因组学.
  • 进化生物学 进化生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 在真核生物中,替代拼接 (AS) 从单个基因产生多个转录.
  • 现有的数据库缺乏关于跨物种的转录保护和演变的全面数据.
  • 识别保存的转录有助于理解同源性,功能和遗传学关系.

研究的目的:

  • 开发TranscriptDB,这是一个专门的资源,用于研究基因家族内的转录保存和进化.
  • 为多个真核生物物种提供保存的转录和原始物种的目录.
  • 为了促进基因和转录进化的探索.

主要方法:

  • 编译了来自Ensembl数据库111版本的317种真核生物物种的保存转录数据和系谱.
  • 开发了一个用户友好的Web界面,用于浏览和查询数据库.
  • 集成的Web服务器用于分析用户提交的数据,以及用于程序访问的REST API.

主要成果:

  • 转录DB提供了一个广泛的列表,涵盖了317个注释的真核生物物种的保存转录和字系.
  • 该数据库促进了对基因和转录进化的研究,包括同类学和遗传学重建.
  • 可访问的数据包括Web界面,Web服务器,REST API和批量下载选项.

结论:

  • 转录DB解决了研究转录保存和演变的资源缺口.
  • 该数据库为研究研究真核生物基因和转录进化的研究人员提供了宝贵的工具.
  • 转录DB是免费访问的,促进了进化转录学研究的更广泛研究.