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Updated: Jun 7, 2025

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
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在基因工程癌症小鼠模型中探索放射性免疫结合物和Fcγ受体之间的相互作用

Cindy Rodriguez1,2,3, Samantha M Sarrett1,2,4, Joni Sebastiano1,2,4

  • 1Department of Chemistry, Hunter College, City University of New York, New York 10021, New York, United States.

ACS pharmacology & translational science
|November 14, 2024
PubMed
概括

内源性IgG的存在会影响Fc玛受体 (FcγR) 如何影响小鼠中的放射性标记抗体药理动力学. 这一发现对于开发有效的癌症免疫疗法至关重要.

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Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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