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基于Box-Cox的接收器运行特征曲线的统计推理.
Leonidas E Bantis1, Benjamin Brewer1, Christos T Nakas2,3
1Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, KS, USA.
Statistics in medicine
|November 17, 2024
概括
本研究通过考虑Box-Cox转换参数的可变性来解决接收器操作特征 (ROC) 曲线分析中的挑战. 一个新的R包,
科学领域:
- 生物统计学 生物统计学
- 医学诊断 医学诊断 医学诊断
- 统计建模 统计建模
背景情况:
- 接收器操作特征 (ROC) 曲线分析对于评估诊断测试和生物标志物至关重要.
- 对于ROC曲线的参数统计推理通常使用Box-Cox转换到正常.
- 一个关键的挑战是准确计算估计的Box-Cox转换参数的变化率,这通常被忽视.
研究的目的:
- 审查ROC分析中的Box-Cox转换的文献.
- 提出一种方法来纳入Box-Cox参数的估计可变性.
- 开发一个关于ROC曲线函数的统计推理的一般框架.
主要方法:
- 在ROC分析中对Box-Cox转换应用的文献综述.
- 开发一个统计框架,以计算Box-Cox转换参数的估计.
- 该框架应用于各种诊断准确度指标 (AUC,尤登指数等). ) 的情况.
主要成果:
- 对现有文献和方法的全面审查.
- 一个用于ROC分析的一般推断框架,包含Box-Cox参数可变性.
- 开发和发布"rocbc" R包,以便实际实施.
结论:
- 在ROC分析中准确的统计推断需要考虑Box-Cox转换参数估计.
- 拟议的框架和"rocbc"包为ROC曲线分析提供了强大的工具.
- 这项工作提高了诊断测试和生物标志物评估的可靠性.
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