Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Randomized Experiments01:13

Randomized Experiments

6.7K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
6.7K
Blinding01:11

Blinding

2.4K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
2.4K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

121
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
121
Comparing the Survival Analysis of Two or More Groups01:20

Comparing the Survival Analysis of Two or More Groups

152
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
152
Group Design02:01

Group Design

8.9K
The most basic experimental design involves two groups: the experimental group and the control group. The two groups are designed to be the same except for one difference— experimental manipulation. The experimental group gets the experimental manipulation—that is, the treatment or variable being tested—and the control group does not. Since experimental manipulation is the only difference between the experimental and control groups, we can be sure that any differences between...
8.9K
Crossover Experiments01:16

Crossover Experiments

2.7K
Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
2.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Sample Size Determination for Response-Adaptive Randomization With Recurrent Event Responses and Unequal Follow-Up Time.

Statistics in medicine·2026
Same author

Arthralgia and Ultrasound Characteristics of Subclinical Psoriatic Arthritis: A Cross-Sectional Study Based on the SPAWCH Cohort.

The Journal of dermatology·2026
Same author

Efficient interaction analysis in randomized controlled trials.

Biometrics·2026
Same author

Racial and ethnic disparities in access to acute stroke capabilities in California: Association with rurality and telestroke access.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2026
Same author

DDR2 ameliorates nonalcoholic hepatic steatosis by activating the AMPK/ACC pathway.

Scientific reports·2026
Same author

Anatomical observation of phrenic nerve branch variations at the cervicothoracic junction and upper mediastinum: two case reports.

Folia morphologica·2026
Same journal

Optimal Weighted Tests for Replication Studies and the 'Two-Trials Rule' With Multiple Hypotheses.

Statistics in medicine·2026
Same journal

Identifiable Copula-Double-Cox Models: A Fully Parametric Framework for Dependent Right-Censored Survival Data.

Statistics in medicine·2026
Same journal

Moving From Individualized Risk-Based Prevention to Benefit-Based Prevention: Estimating Individualized Life-Years Gained From Prevention Services as a Basis for Eligibility.

Statistics in medicine·2026
Same journal

A Mixture of Distributed Lag Non-Linear Models to Account for Spatially Heterogeneous Exposure-Lag-Response Associations.

Statistics in medicine·2026
Same journal

Practical Considerations for Gaussian Process Modeling for Causal Inference in Quasi-Experimental Studies With Panel Data.

Statistics in medicine·2026
Same journal

Covariate Adjustment for Wilcoxon Two Sample Statistic and Test.

Statistics in medicine·2026
查看所有相关文章

相关实验视频

Updated: Jun 6, 2025

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

14.4K

临床试验中的响应适应性随机化程序,使用代用终点.

Jingya Gao1, Feifang Hu2, Wei Ma3

  • 1School of Mathematics and Physics, University of Science and Technology Beijing, Beijing, China.

Statistics in medicine
|November 25, 2024
PubMed
概括
此摘要是机器生成的。

响应适应性随机化 (RAR) 在临床试验中可能具有挑战性,当主要终点被延迟时. 这项研究建议使用RAR的替代终点,确保患者的益处和有效的统计推断,即使具有有限的初级结果数据.

关键词:
异常常态的正常性.延迟反应 延迟反应响应 - 适应性随机化替代终点 替代终点测试功率 测试功率 测试功率第一种类型的错误率.

更多相关视频

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

411
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
00:04

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.6K

相关实验视频

Last Updated: Jun 6, 2025

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

14.4K
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

411
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
00:04

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.6K

科学领域:

  • 临床试验 临床试验
  • 生物统计学 生物统计学
  • 医学研究方法学 医学研究方法学

背景情况:

  • 在临床试验中,顺序性受试者招募是标准的.
  • 响应适应性随机化 (RAR) 优化了基于累积试验数据的治疗分配.
  • 招募期间有限的初级终点数据阻碍了RAR应用,特别是在公共卫生紧急情况或慢性疾病中.

研究的目的:

  • 提出一种新的RAR程序,在初级终点不可用时使用代用终点.
  • 为了证明RAR与代用终点的有效性和患者益处.
  • 探索这种方法在不同替代品和初级终点类型中的性能.

主要方法:

  • 开发一种响应适应性随机化程序,仅依赖替代终点.
  • 对于主要终点的统计推理有效性的理论理由.
  • 模拟研究,以评估患者的益处和方法的性能.

主要成果:

  • 建议使用替代终点的RAR程序在统计学上是有效的.
  • 模拟证实了该方法的可行性和患者的益处.
  • 在各种代用药和初级终点组合中证明了有效性.

结论:

  • 使用替代终点的RAR为延迟初级结果的临床试验提供了可行的解决方案.
  • 这种方法在具有挑战性的招聘场景中提高了治疗分配效率和患者利益.
  • 当初始数据稀缺时,代用终点为适应性试验设计提供了切实可行的替代方案.