格雷夫病和微细胞性贫血:一个被遗忘的联系
1Department of Biology, University of Pennsylvania, Philadelplhia, PA, USA.
The American journal of case reports
|November 26, 2024
概括
甲状腺毒性病可以通过破坏红细胞的产生引起微细胞性贫血. 高甲状腺症的治疗解决了贫血,这表明甲状腺激素和红细胞大小之间存在直接联系.
科学领域:
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
背景情况:
- 微细胞性贫血很少与甲状腺毒性有关,最近的文献有限.
- 这种关联的基本机制仍然不太清楚.
研究的目的:
- 为了呈现一种同时出现甲状腺功能过高和微细胞贫血的病例.
- 提出一种用于甲状腺毒素症诱导的微细胞贫血的分子机制.
- 为了强调在患有不明原因的微细胞贫血的患者中考虑甲状腺功能的重要性.
主要方法:
- 一个56岁的男性患有格雷夫斯病和微细胞贫血的病例报告.
- 用甲基马治疗甲状腺功能障碍的治疗.
- 监测甲状腺功能,红细胞参数和铁研究 (血清费里丁).
主要成果:
- 患者呈现甲状腺功能过高和微细胞贫血,没有缺铁.
- 甲基马治疗解决了甲状腺功能障碍,并使红细胞参数正常化.
- 血清费里丁水平随着治疗而降低,这表明细胞铁利用率或周转率降低.
结论:
- 超生理性甲状腺激素 (T3) 水平在红细胞前体中诱导蛋白质毒性压力.
- 这种压力激活了综合应激反应,导致eIF2.2的酸化.
- 损伤的全球蛋白mRNA翻译导致全球蛋白合成和微细胞分裂的减少,模仿thalassemia.
更多相关视频
09:50Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice
Published on: February 11, 2019
9.7K
06:35An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
7.1K
相关概念视频
Disorders of Erythrocytes
861
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
861
Vitamins
563
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
563
Autoimmune Disorders
389
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
389
Myasthenia Gravis: Diagnostic Tests
653
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
653
Myasthenia Gravis: Overview and Treatment
1.2K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.2K
Translation
14.6K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
Translation Produces the Building Blocks of Life
Proteins are...
14.6K
