创伤后应激障碍通过PVN激活和Sprague Dawley大鼠的血管功能障碍增加高血压发展的风险.
Xinqian Chen1,2, Xin Yan2,3, Chunxiu Yu2,4
1Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI 49931, USA.
Antioxidants (Basel, Switzerland)
|November 27, 2024
概括
单一的长期压力 (SPS),创伤后应激障碍 (PTSD) 的模型,主要是心血管路径. 这种压力模型增加了氧化压力和炎症,可能导致高血压和未来的压力因素.
科学领域:
- 神经科学是一个神经科学.
- 心血管科学 心血管科学
- 压力生理学 压力生理学
背景情况:
- 创伤后应激障碍 (PTSD) 与心血管问题有关.
- 单一长期压力 (SPS) 是一种模拟PTSD的动物模型.
- 连接压力,大脑和心血管功能障碍的机制需要阐明.
研究的目的:
- 为了研究SPS对心血管反应的影响,下丘脑副心室核 (PVN) 活动和血管功能.
- 探索将创伤性压力与高血压联系起来的分子机制.
- 确定与压力有关的心血管疾病的潜在治疗点.
主要方法:
- 雄性斯普拉格·道利大鼠接受了SPS.
- 对心血管参数 (血压,心率) 进行监测.
- 在PVN和大动脉中分析了基因表达 (血压素,AT1R,FOSL1,TNFα,IL1β,iNOS).
- 评估了线粒体反应性氧物种 (mtROS) 和血管反应性.
主要成果:
- SPS诱导血压和心率的短暂增加,但不是慢性高血压.
- 在PVN中观察到高血压相关基因 (血压素,AT1R,FOSL1) 的改变表达.
- 升高的mtROS与PVN中的AT1R和FOSL1共定位,表明氧化应激放大.
- SPS增加了主动脉中的促炎性细胞因子和iNOS,损害了血管功能.
结论:
- SPS使神经内分泌,自主和血管通路敏感,造成心血管脆弱性.
- 氧化应激和改变的PVN通路是将压力与心血管功能障碍联系起来的关键机制.
- 准氧化应激和PVN通路可能会减轻PTSD对心血管的影响.
更多相关视频
06:00Author Spotlight: Deciphering the Long-Term Effects of Low-Level Blast Exposures in Mice
Published on: May 24, 2024
857
06:55An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
22.4K
相关概念视频
01:27Post-traumatic Stress Disorder
29
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
29
01:27Psychoneuroimmunology: Cardiovascular Disease
25
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
25
01:18Disorders of the Autonomic Nervous System
565
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
565