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Updated: May 7, 2026

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"从头到尾"宏循环PROTAC的基于结构的设计

Chungen Li1, Yihan Chen1,2, Weixue Huang1

  • 1State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, No. 345 Lingling Road, Shanghai 200032, China.

JACS Au
|December 30, 2024
PubMed
概括

宏循环使SHD913这样的新型蛋白质分解向化马 (PROTAC) 能够克服强大的Brd4降解的效应,并改善癌细胞的代谢稳定性.

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